Publications
- Luciferase Reporter Genes Detection
- Bioluminescent ATP Assay
- Carbonylated Proteins Fluorescent Assay
- Chemiluminescent Western Blot Revelation
- Glucose Uptake
- Nos collaborations
Bénédicte Gaborit, Roland Govers, Alexandre Altié, Jean Michel Brunel, Pierre Morange, et al.. The aminosterol Claramine inhibits β-secretase 1–mediated insulin receptor cleavage. Journal of Biological Chemistry 2021; 297 (1), 100818. doi: 10.1016/j.jbc.2021.100818.
Roblin C, Chiumento S, Jacqueline C, Pinloche E, Nicoletti C, Olleik H, Courvoisier-Dezord E, Amouric A, Basset C, Dru L, Ollivier M, Bogey-Lambert A, Vidal N, Atta M, Maresca M, Devillard E, Duarte V, Perrier J, Lafond M. The Multifunctional Sactipeptide Ruminococcin C1 Displays Potent Antibacterial Activity In Vivo as Well as Other Beneficial Properties for Human Health. Int. J. Mol. Sci. 2021; 22 (6): 3253. doi: 10.3390/ijms22063253.
Peiretti F, Montanari R, Capelli D, Bonardo B, Colson C, Amri EZ, Grimaldi M, Balaguer P, Ito K, Roeder RG, Pochetti G, Brunel JM. A Novel N-Substituted Valine Derivative with Unique Peroxisome Proliferator-Activated Receptor γ Binding Properties and Biological Activities. J. Med. Chem. 2020; 63 (21): 13124-13139. doi: 10.1021/acs.jmedchem.0c01555.
Nada Zabaiou, Allan Fouache, Amalia Trousson, Julio Buñay-Noboa, Geoffroy Marceau, Vincent Sapin, Amar Zellagui, Silvère Baron, Mesbah Lahouel, Jean-Marc A. Lobaccaro. Ethanolic extract of Algerian propolis decreases androgen receptor transcriptional activity in cultured LNCaP cells. J. Steroid. Biochem. Mol. Biol. 2019; 189: 108-115. doi: 10.1016/j.jsbmb.2019.02.016.
Fouache A, Zabaiou N, De Joussineau C, Morel L, Silvente-Poirot S, Namsi A, Lizard G, Poirot M, Makishima M, Baron S, Lobaccaro JA, Trousson A. Flavonoids differentially modulate liver X receptors activity-Structure-function relationship analysis. J. Steroid. Biochem. Mol. Biol. 2019; 190: 173-182. doi: 10.1016/j.jsbmb.2019.03.028.
Terol M, Gazon H, Lemasson I, Duc-Dodon M, Barbeau B, Césaire R, Mesnard JM, Péloponèse JM Jr. HBZ-mediated shift of JunD from growth suppressor to tumor promoter in leukemic cells by inhibition of ribosomal protein S25 expression. Leukemia 2017; 31 (10): 2235-2243. doi: 10.1038/leu.2017.74.
Gazon H, Belrose G, Terol M, Meniane JC, Mesnard JM, Césaire R, Peloponese JM Jr. Impaired expression of DICER and some microRNAs in HBZ expressing cells from acute adult T-cell leukemia patients. Oncotarget. 2016; 7 (21): 30258-75. doi: 10.18632/oncotarget.7162.
Loubeau G, Boudra R, Maquaire S, Lours-Calet C, Beaudoin C, Verrelle P, Morel L. NPM1 silencing reduces tumour growth and MAPK signalling in prostate cancer cells. PLoS One 2014; 9 (5): e96293. doi: 10.1371/journal.pone.0096293.
Berthon A, Drelon C, Ragazzon B, Boulkroun S, Tissier F, Amar L, Samson-Couterie B, Zennaro MC, Plouin PF, Skah S, Plateroti M, Lefèbvre H, Sahut-Barnola I, Batisse-Lignier M, Assié G, Lefrançois-Martinez AM, Bertherat J, Martinez A, Val P. WNT/β-catenin signalling is activated in aldosterone-producing adenomas and controls aldosterone production. Hum. Mol. Genet. 2014; 23 (4): 889-905. doi: 10.1093/hmg/ddt484.
Gazon H, Lemasson I, Polakowski N, Césaire R, Matsuoka M, Barbeau B, Mesnard JM, Peloponese JM Jr. Human T-cell leukemia virus type 1 (HTLV-1) bZIP factor requires cellular transcription factor JunD to upregulate HTLV-1 antisense transcription from the 3′ long terminal repeat. J. Virol. 2012; 86 (17): 9070-8. doi: 10.1128/JVI.00661-12.
Lefrancois-Martinez AM, Blondet-Trichard A, Binart N, Val P, Chambon C, Sahut-Barnola I, Pointud JC, Martinez A. Transcriptional control of adrenal steroidogenesis: novel connection between Janus kinase (JAK) 2 protein and protein kinase A (PKA) through stabilization of cAMP response element-binding protein (CREB) transcription factor. J. Biol. Chem. 2011; 286 (38): 32976-85. doi: 10.1074/jbc.M111.218016.
Clerc, I., Laverdure, S., Torresilla, C. et al.Polarized expression of the membrane ASP protein derived from HIV-1 antisense transcription in T cells. Retrovirology 2011; 8: 74. doi: 10.1186/1742-4690-8-74.
Clerc I, Polakowski N, André-Arpin C, Cook P, Barbeau B, Mesnard JM, Lemasson I. An interaction between the human T cell leukemia virus type 1 basic leucine zipper factor (HBZ) and the KIX domain of p300/CBP contributes to the down-regulation of tax-dependent viral transcription by HBZ. J. Biol. Chem. 2008; 283 (35): 23903-13. doi: 10.1074/jbc.M803116200.
Val P, Martinez-Barbera JP, Swain A. Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage. Development 2007; 134 (12): 2349-58. doi: 10.1242/dev.004390.
Lécine P, Esmiol S, Métais JY, Nicoletti C, Nourry C, McDonald C, Nunez G, Hugot JP, Borg JP, Ollendorff V. The NOD2-RICK complex signals from the plasma membrane. J. Biol. Chem. 2007; 282 (20): 15197-207. doi: 10.1074/jbc.M606242200.
Arpin-André C, Mesnard JM. The PDZ domain-binding motif of the human T cell leukemia virus type 1 tax protein induces mislocalization of the tumor suppressor hScrib in T cells. J. Biol. Chem. 2007; 282 (45): 33132-41. doi: 10.1074/jbc.M702279200.
Ragazzon B, Lefrançois-Martinez AM, Val P, Sahut-Barnola I, Tournaire C, Chambon C, Gachancard-Bouya JL, Begue RJ, Veyssière G, Martinez A. Adrenocorticotropin-dependent changes in SF-1/DAX-1 ratio influence steroidogenic genes expression in a novel model of glucocorticoid-producing adrenocortical cell lines derived from targeted tumorigenesis. Endocrinology 2006; 147 (4): 1805-18. doi: 10.1210/en.2005-1279.
Pierre Val, Christelle Aigueperse, Bruno Ragazzon, Georges Veyssière, Anne-Marie Lefrançois-Martinez, Antoine Martinez, Adrenocorticotropin/3′,5′-Cyclic AMP-Mediated Transcription of the Scavenger akr1-b7Gene in Adrenocortical Cells Is Dependent on Three Functionally Distinct Steroidogenic Factor-1-Responsive Elements. Endocrinology 2004; 145 (2): 508–518. doi: 10.1210/en.2003-1093.
Petrocchi C, Thétiot-Laurent S, Culcasi M, Pietri S. Novel Mitochondria-Targeted Triphenylphosphonium Conjugates of Linear β-Phosphorylated Nitrones : Preparation, 31P NMR Mitochondrial Distribution, EPR Spin Trapping Reporting, and Site-Directed Antiapoptotic Properties. Methods Mol. Biol. 2021; 2275: 65-85. doi: 10.1007/978-1-0716-1262-0_5.
Roblin C, Chiumento S, Bornet O, Nouailler M, Müller CS, Jeannot K, Basset C, Kieffer-Jaquinod S, Couté Y, Torelli S, Le Pape L, Schünemann V, Olleik H, De La Villeon B, Sockeel P, Di Pasquale E, Nicoletti C, Vidal N, Poljak L, Iranzo O, Giardina T, Fons M, Devillard E, Polard P, Maresca M, Perrier J, Atta M, Guerlesquin F, Lafond M, Duarte V. The unusual structure of Ruminococcin C1 antimicrobial peptide confers clinical properties. Proc. Natl. Acad. Sci. USA 2020; 117 (32): 19168-19177. doi: 10.1073/pnas.2004045117.
Cadelis MM, Pike EIW, Kang W, Wu Z, Bourguet-Kondracki ML, Blanchet M, Vidal N, Brunel JM, Copp BR. Exploration of the antibiotic potentiating activity of indolglyoxylpolyamines. Eur. J. Med. Chem. 2019; 183: 111708. doi: 10.1016/j.ejmech.2019.111708.
Li SA, Cadelis MM, Sue K, Blanchet M, Vidal N, Brunel JM, Bourguet-Kondracki ML, Copp BR. 6-Bromoindolglyoxylamido derivatives as antimicrobial agents and antibiotic enhancers. Bioorg. Med. Chem. 2019; 27 (10): 2090-2099. doi: 10.1016/j.bmc.2019.04.004.
Blanchet M, Borselli D, Rodallec A, Peiretti F, Vidal N, Bolla JM, Digiorgio C, Morrison KR, Wuest WM, Brunel JM. Claramines: A New Class Of Broad-Spectrum Antimicrobial Agents With Bimodal Activity. Chem. Med. Chem. 2018; 13 (10): 1018-1027. doi: 10.1002/cmdc.201800073.
Kandouli C, Cassien M, Mercier A, Delehedde C, Ricquebourg E, Stocker P, Mekaouche M, Leulmi Z, Mechakra A, Thétiot-Laurent S, Culcasi M, Pietri S. Antidiabetic, antioxidant and anti inflammatory properties of water and n-butanol soluble extracts from Saharian Anvillea radiata in high-fat-diet fed mice. J. Ethnopharmacol. 2017; 207: 251-267. doi: 10.1016/j.jep.2017.06.042.
Boudra R, Lagrafeuille R, Lours-Calet C, de Joussineau C, Loubeau-Legros G, Chaveroux C, Saru JP, Baron S, Morel L, Beaudoin C. mTOR transcriptionally and post-transcriptionally regulates Npm1 gene expression to contribute to enhanced proliferation in cells with Pten inactivation. Cell Cycle 2016; 15 (10): 1352-62. doi: 10.1080/15384101.2016.1166319.
Vidal N, Cavaille JP, Graziani F, Robin M, Ouari O, Pietri S, Stocker P. High throughput assay for evaluation of reactive carbonyl scavenging capacity. Redox Biol. 2014; 2: 590-8. doi: 10.1016/j.redox.2014.01.016.
Pieri C, Borselli D, Di Giorgio C, De Méo M, Bolla JM, Vidal N, Combes S, Brunel JM. New Ianthelliformisamine derivatives as antibiotic enhancers against resistant Gram-negative bacteria. J. Med. Chem. 2014; 57 (10): 4263-72. doi: 10.1021/jm500194e.
Lucie Paloque, Nicolas Vidal, Magali Casanova, Aurélien Dumètre, Pierre Verhaeghe, Daniel Parzy, Nadine Azas. A new, rapid and sensitive bioluminescence assay for drug screening on Leishmania. Journal of Microbiological Methods 2013; 95 (3): 320-323. doi : 10.1016/j.mimet.2013.09.006.
Razafimanjato H, Benzaria A, Taïeb N, Guo XJ, Vidal N, Di Scala C, Varini K, Maresca M. The ribotoxin deoxynivalenol affects the viability and functions of glial cells. Glia 2011; 59 (11): 1672-83. doi: 10.1002/glia.21214.
Lesgards JF, Gauthier C, Iovanna J, Vidal N, Dolla A, Stocker P. Effect of reactive oxygen and carbonyl species on crucial cellular antioxidant enzymes. Chem. Biol. Interact. 2011; 190 (1): 28-34. doi: 10.1016/j.cbi.2010.12.028.
Alhanout K, Malesinki S, Vidal N, Peyrot V, Rolain JM, Brunel JM. New insights into the antibacterial mechanism of action of squalamine. J. Antimicrob. Chemother. 2010; 65 (8): 1688-93. doi: 10.1093/jac/dkq213.
Lafond, M; Vidal, N; Letourneux, Y; Brunel, JM. A comparison of three rapid and accurate bioluminescent antibiotic susceptibility tests. Journal of Pharmacological and Toxicological Methods 2010; 61 (1): 16-19, doi:10.1016/j.vascn.2009.10.004.
Carraro V, Maurin AC, Lambert-Langlais S, Averous J, Chaveroux C, Parry L, Jousse C, Ord D, Ord T, Fafournoux P, Bruhat A. Amino acid availability controls TRB3 transcription in liver through the GCN2/eIF2α/ATF4 pathway. PLoS One 2010; 5 (12): e15716. doi: 10.1371/journal.pone.0015716.
Fenard D, Houzet L, Bernard E, Tupin A, Brun S, Mougel M, Devaux C, Chazal N, Briant L. Uracil DNA Glycosylase 2 negatively regulates HIV-1 LTR transcription. Nucleic Acids Res. 2009; 37 (18): 6008-18. doi: 10.1093/nar/gkp673.
Henry-Berger J, Mouzat K, Baron S, Bernabeu C, Marceau G, Saru JP, Sapin V, Lobaccaro JM, Caira F. Endoglin (CD105) expression is regulated by the liver X receptor alpha (NR1H3) in human trophoblast cell line JAR. Biol. Reprod. 2008; 78 (6): 968-75. doi: 10.1095/biolreprod.107.066498.
Salmi C, Loncle C, Vidal N, Letourneux Y, Fantini J, Maresca M, Taïeb N, Pagès JM, Brunel JM. Squalamine: an appropriate strategy against the emergence of multidrug resistant gram-negative bacteria? PLoS One 2008; 3 (7): e2765. doi: 10.1371/journal.pone.0002765.
Léotoing L, Meunier L, Manin M, Mauduit C, Decaussin M, Verrijdt G, Claessens F, Benahmed M, Veyssière G, Morel L, Beaudoin C. Influence of nucleophosmin/B23 on DNA binding and transcriptional activity of the androgen receptor in prostate cancer cell. Oncogene 2008; 27 (20): 2858-67. doi: 10.1038/sj.onc.1210942.
Chérasse Y, Maurin AC, Chaveroux C, Jousse C, Carraro V, Parry L, Deval C, Chambon C, Fafournoux P, Bruhat A. The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP. Nucleic Acids Res. 2007; 35 (17): 5954-65. doi: 10.1093/nar/gkm642.
Volle DH, Repa JJ, Mazur A, Cummins CL, Val P, Henry-Berger J, Caira F, Veyssiere G, Mangelsdorf DJ, Lobaccaro JM. Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes. Mol. Endocrinol. 2004; 18 (4): 888-98. doi: 10.1210/me.2003-0338.
Stocker P, Cassien M, Vidal N, Thétiot-Laurent S, Pietri S. A fluorescent homogeneous assay for myeloperoxidase measurement in biological samples. A positive correlation between myeloperoxidase-generated HOCl level and oxidative status in STZ-diabetic rats. Talanta 2017; 170: 119-127. doi: 10.1016/j.talanta.2017.03.102.
Stocker P, Ricquebourg E, Vidal N, Villard C, Lafitte D, Sellami L, Pietri S. Fluorimetric screening assay for protein carbonyl evaluation in biological samples. Anal. Biochem. 2015; 482: 55-61. doi: 10.1016/j.ab.2015.04.021.
Vidal N, Cavaille JP, Graziani F, Robin M, Ouari O, Pietri S, Stocker P. High throughput assay for evaluation of reactive carbonyl scavenging capacity. Redox Biol. 2014; 2: 590-8. doi: 10.1016/j.redox.2014.01.016.
Lesgards JF, Gauthier C, Iovanna J, Vidal N, Dolla A, Stocker P. Effect of reactive oxygen and carbonyl species on crucial cellular antioxidant enzymes. Chem. Biol. Interact. 2011; 190 (1): 28-34. doi: 10.1016/j.cbi.2010.12.028.
Gomez D, Guédin A, Mergny JL, Salles B, Riou JF, Teulade-Fichou MP, Calsou P. A G-quadruplex structure within the 5′-UTR of TRF2 mRNA represses translation in human cells. Nucleic Acids Res. 2010; 38 (20): 7187-98. doi: 10.1093/nar/gkq563.
Britton S, Frit P, Biard D, Salles B, Calsou P. ARTEMIS nuclease facilitates apoptotic chromatin cleavage. Cancer Res. 2009; 69 (20): 8120-6. doi: 10.1158/0008-5472.CAN-08-4400.
Britton S, Salles B, Calsou P. c-MYC protein is degraded in response to UV irradiation. Cell Cycle 2008; 7 (1): 63-70. doi: 10.4161/cc.7.1.5111.
Laghezza A, Piemontese L, Cerchia C, Montanari R, Capelli D, Giudici M, Crestani M, Tortorella P, Peiretti F, Pochetti G, Lavecchia A, Loiodice F. Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation. J. Med. Chem. 2018; 61 (18): 8282-8298. doi: 10.1021/acs.jmedchem.8b00835.
Brusotti G, Montanari R, Capelli D, Cattaneo G, Laghezza A, Tortorella P, Loiodice F, Peiretti F, Bonardo B, Paiardini A, Calleri E, Pochetti G. Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis. Sci Rep. 2017; 7 (1): 5777. doi: 10.1038/s41598-017-05666-6.
Kara I, Poggi M, Bonardo B, Govers R, Landrier JF, Tian S, Leibiger I, Day R, Creemers JW, Peiretti F. The paired basic amino acid-cleaving enzyme 4 (PACE4) is involved in the maturation of insulin receptor isoform B: an opportunity to reduce the specific insulin receptor-dependent effects of insulin-like growth factor 2 (IGF2). J. Biol. Chem. 2015; 290 (5): 2812-21. doi: 10.1074/jbc.M114.592543.
Vidal N, Cavaillé JP, Poggi M, Peiretti F, Stocker P. A nonradioisotope chemiluminescent assay for evaluation of 2-deoxyglucose uptake in 3T3-L1 adipocytes. Effect of various carbonyls species on insulin action. Biochimie 2012; 94 (12): 2569-76. doi: 10.1016/j.biochi.2012.07.006.
Cassien, M.; Mercier, A.; Thétiot-Laurent, S.; Culcasi, M.; Ricquebourg, E.; Asteian, A.; Herbette, G.; Bianchini, J.-P.; Raharivelomanana, P.; Pietri, S. Improving the Antioxidant Properties of Calophyllum inophyllum Seed Oil from French Polynesia: Development and Biological Applications of Resinous Ethanol-Soluble Extracts. Antioxidants 2021; 10: 199. doi: 10.3390/antiox10020199.
Castro Marin A, Stocker P, Chinnici F, Cassien M, Thétiot-Laurent S, Vidal N, Riponi C, Robillard B, Culcasi M, Pietri S. Inhibitory effect of fungoid chitosan in the generation of aldehydes relevant to photooxidative decay in a sulphite-free white wine. Food Chem. 2021; 350: 129222. doi: 10.1016/j.foodchem.2021.129222.
Dedieu, L.; Brunel, J.M.; Lorenzi, V.; Muselli, A.; Berti, L.; Bolla, J.M. Antibacterial Mode of Action of the Daucus carota Essential Oil Active Compounds against Campylobacter jejuni and Efflux-Mediated Drug Resistance in Gram-Negative Bacteria. Molecules 2020; 25: 5448. doi: 10.3390/molecules25225448.
Tranchida, F., Rakotoniaina, Z., Shintu, L. et al. Hepatic metabolic effects of Curcuma longa extract supplement in high-fructose and saturated fat fed rats. Sci. Rep. 2017; 7: 5880. doi: 10.1038/s41598-017-06220-0.
Benameur L, Auffan M, Cassien M, Liu W, Culcasi M, Rahmouni H, Stocker P, Tassistro V, Bottero JY, Rose J, Botta A, Pietri S. DNA damage and oxidative stress induced by CeO2 nanoparticles in human dermal fibroblasts: Evidence of a clastogenic effect as a mechanism of genotoxicity. Nanotoxicology 2015;9 (6): 696-705. doi: 10.3109/17435390.2014.968889.
Lesgards JF, Baldovini N, Vidal N, Pietri S. Anticancer activities of essential oils constituents and synergy with conventional therapies: a review. Phytother. Res. 2014; 28 (10): 1423-46. doi: 10.1002/ptr.5165.
Bordignon B, Mones S, Rahman F, Chiron J, Peiretti F, Vidal N, Fontes M. A derivative of ascorbic acid modulates cAMP production. Biochem. Biophys. Res. Commun. 2013; 439 (1): 137-41. doi: 10.1016/j.bbrc.2013.08.004.
Guillaumond F, Leca J, Olivares O, Lavaut MN, Vidal N, Berthezène P, Dusetti NJ, Loncle C, Calvo E, Turrini O, Iovanna JL, Tomasini R, Vasseur S. Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma. Proc. Natl. Acad. Sci. USA 2013; 110(10): 3919-24. doi: 10.1073/pnas.1219555110.
Sanaa Tazi, Antoine Puigserver, El Hassan Ajandouz. A novel, fast and accurate chemiluminescence method for measuring lipoxidation in almonds and almond-based products during processing and storage. Food Chemestry 2009; 116 (4): 999-1004. doi: 10.1016/j.foodchem.2009.03.054.
Mevy JP, Bessiere JM, Dherbomez M, Viano J. Composition and some biological activities of the essential oils from an African pasture grass: Elionurus elegans Kunth. J. Agric. Food. Chem. 2002; 50(15): 4240-3. doi: 10.1021/jf0115140.